New Step by Step Map For cees dekker
New Step by Step Map For cees dekker
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Employing single-molecule optical and AFM imaging and force-spectroscopy approaches, we find to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research pursuits contain:
It was only during the nineties while, when nanotechnology had Highly developed into a amount wherever single molecules may very well be manipulated, that the initial experimental equipment began to look.
[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was effectively conscious that it could go Incorrect and that I could become significantly less prosperous, but I just overlooked that. Curiosity has generally been my strongest driving power. And fortuitously it all labored out.’
Our work was quickly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors created from solitary- and multi-walled carbon nanotubes in Applied Physics Letters.
That could be a desire of mine and we set to operate with a delightful dose of naivety. This is something which will most likely generate magnificent ends in the longer phrase, but that doesn't make any difference. You should not only want to work about the thoughts of tomorrow, but additionally about the thoughts in the working day just after tomorrow.’
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of an individual wire bridging two electrodes
What distinguishes biology from chemistry is these factors collectively make up a dwelling method. The trick of mentioned everyday living, I believe, lies during the interactions, the interplay of All those molecules. The large dilemma in regards to the origin of everyday living continues to be unanswered. How did we at ceesdekker any time evolve from simple molecules to the exceptionally sophisticated units we see these days? We don't know. I need to work on These types of significant, open inquiries.’
2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore sophisticated; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination
The rotors harness Strength from a nanoscale h2o and ion circulation which is created by a static chemical or electrochemical probable gradient inside the nanopore, that are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting ways to setting up Electricity-transducing motors at nanoscale interfaces.
Quite neat, but that wasn’t actually wherever my interest lay. I desired to pioneer And that i experienced the sensation that was not doable, as the most fascinating basic insights experienced now been uncovered. But my area had designed lots of thrilling new equipment to evaluate unique molecules. I made a decision that I desired to use this to biology, to take a look at it from the Actual physical standpoint.’
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
Afterwards we spoke yet again briefly because Dekker felt that our discussion of his faith speedily turned purely philosophical, Whilst Additionally, it concretely will help him in his get the job done.
Visualization of unstained DNA nanostructures with Superior in-emphasis transmission electron microscopy procedures
The biophysicist from Delft – who is Just about the most cited scientists in the Netherlands For some time – can take his accountability to contribute to the rationalization and popularisation of his operate on the border of physics and biology very seriously and consistently appears in the media; Otherwise to speak about his function, then about the connection amongst science and his Christian faith.